中国肺癌杂志2016，Vol.19Issue(5)：269-278,10.DOI:10.3779/j.issn.1009-3419.2016.05.04
CT引导射频消融与瘤内化疗治疗早期非小细胞肺癌的临床研究
CT Guided Radiofrequency Ablation Followed Intratumoral Chemotherapy in the Treatment of Early Stage Non-small Cell Lung Cancer
摘要
Abstract
Background and objectiveRadiofrequency ablation (RFA) has become one of the local treatment for inoperable early stage non-small cell lung cancer (NSCLC). hTis study observes effectiveness and safety of computed tomog-raphy (CT) guided RFA followed intratumoral chemotherapy (RFA-ITC).MethodsFrom 2005 to 2015, our group perspec-tively enrolled inoperable early stage NSCLC underwent RFA-ITC duo to poor cardiopulmonary function or with other dis-eases or patient can't tolerate or reject surgery. RFA was performed by a directive apparatus assisted CT guided semi real-time and step-by-step puncture method, conformal umbrella-shaped electrode and single or multiple targets ablation. While the plan ifnished and CT showed normal lung tissue around the tumor present ground-glass opacity (GGO), the procedure ended, then 200 mg of carboplatinum were injected into the tumor via the electrode needle. Safety and effectiveness were evaluated byfollow-up.Results Technical success rates of 125 RFA-ITC treatments of 110 patients were 100%. hTe median survival was 48.0 months, overall survival (OS) was 55.4 months, progression-free survival was 55.1 months, 1, 2, 3, 5-year OS rates were 100%, 90.7%, 62.7%, 21.9%, respectively. Survival of GGO presence or not was 68.3 months and 40.1 months, respectively (P=0.001). hTe survival rates of the N1 staging and tumor size was no signiifcant difference. No perioperative deaths occurred, the main complicationsi.e. pneumothorax, pulmonary hemorrhage, pleural effusion, fever, intraoperative chest pain, subcuta-neous emphysema, intraoperative cough were slight and tolerable.ConclusionCT guided RFA-ITC provides a good method for treatment of inoperable early stage NSCLC with better survival, less complication and small damage.关键词
肺肿瘤/射频消融/瘤内化疗Key words
Lung neoplasms/Radiofrequency ablation/Intratumor chemotherapy引用本文复制引用
冯威健,支修益,李进,韩素红,唐金峰,要洁,崔玉清,王春堂,陈忠诚,李晓光..CT引导射频消融与瘤内化疗治疗早期非小细胞肺癌的临床研究[J].中国肺癌杂志,2016,19(5):269-278,10.基金项目
本研究受北京市科学技术委员会首都临床特色应用研究项目（No.Z131107002213142）资助@@@@This study was supported by the grant from Beijing Municipal Science and Technology Commission Capital Character-istic Clinical Application Research (to Weijian FENG)(No.Z131107002213142) （to Weijian FENG）
