中国肺癌杂志2016，Vol.19Issue(5)：293-298,6.DOI:10.3779/j.issn.1009-3419.2016.05.07
CMR评估肺高血压：肺高血压患者与健康志愿者对照研究
Evaluation of Pulmonary Hypertension with CMR：Pulmonary Hypertension Patients and Healthy Volunteers Control Study
摘要
Abstract
Background and objectivehTe clinical course of pulmonary hypertension (PH) is one of progressive deterioration interspersed with episodes of acute decompensation. It is diffcult to predict when patients will die because death may come either suddenly or slowly due to progressive heart failure. hTe aim of this study is to investigate morphology, func-tion and hemodynamics in PH, compared with healthy people, and to investigate the clinical value of detection of PH by use of cardiac magnetic resonance (CMR) parameters.MethodsCMR was performed in 56 PH patients collected from Tianjin Medical University General Hospital from January 2012 to December 2014 and 22 healthy controls. hTe following parameters were calculated: right ventricle (RV) end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), myocar-dial mass (MM), RV fractional area change (RVFAC), interventricular septal curvature (CIVS), letf ventricular free wall curva-ture (CFW), and CIVS/CFW, main pulmonary artery (MPA) positive peak velocity, maximal area, minimal area and distensibility. Comparisons of CMR measurements between PH patients and controls were analyzed by using the studentt-tests. Receiver operating characteristic (ROC) curve analysis was used to compare the PH diagnostic abilities for four parameters (MPA posi-tive peak velocity, distensibility, curvature ratio, and RVFAC) and combined CMR parameter.P<0.05 was considered signiif-cant.Results Compared with healthy controls, RV morphology, function and hemodynamics of PH group declined and dete-riorate obviously. hTe ROC curve analysis showed that among the four parameters distensibility of MPA had the highest AUC value (AUC=0.95). Additionally, combined CMR parameter (positive peak velocity+distensibility+curvature ratio+RVFAC) had even higher AUC (AUC=0.988).ConclusionComprehensive CMR parameters is conducive to accurately relfect the overall state RV-pulmonary circulation in patients with PH.关键词
心脏/核磁共振/肺高血压/右心室/肺动脉Key words
Cardiac/Magnetic resonance/Pulmonary hypertension/Right ventricle/Pulmonary artery引用本文复制引用
王蒙,杨振文,张璋,李东,杨帆,于铁链..CMR评估肺高血压：肺高血压患者与健康志愿者对照研究[J].中国肺癌杂志,2016,19(5):293-298,6.基金项目
本研究受教育部博士点基金课题（No.20121202110005）、国家自然科学基金项目（No.81301217）、国家临床重点专科建设项目和天津市应用基础与前沿技术研究计划重点项目（No.14JCZDJC57000）资助@@@@This study was supported by the grants from Ph.D. Programs Foundation of Ministry of Education of China (to Tielian YU)(No.20121202110005), National Natural Science Foundation of China (to Zhang ZHANG)(No.81301217), National Key Clinical Specialty Project (to Department of Radiology, Tianjin Medical University General Hospital), and Tianjin Re-search Programme of Application Foundation and Advanced Technology (to Dong LI)(No.14JCZDJC57000) （to Tielian YU）
