中国肺癌杂志2016，Vol.19Issue(5)：299-306,8.DOI:10.3779/j.issn.1009-3419.2016.05.10
骨与软组织肉瘤肺转移的单中心大样本外科治疗结果及预后分析
Treatment Outcomes and Prognostic Factors of Pulmonary Metastasectomy for Bone and Soft Tissue Sarcoma：a High Volume Academic Institution Experience
摘要
Abstract
Background and objective hTe bone and sotf tissue sarcoma can metastasize to distant sites, most commonly the lungs. Some cases can be cured by radical metastasectomy, but its role, indication and prognostic factors remains controversial. hTe rarity of the disease combined with the diverse number of subtypes can make bone and sotf tissue sarco-mas very diffcult to study. hTere are few randomized control studies or international high volume results, and such reports in China are seldom seen. hTe aim of this study is to investigate surgical treatment outcomes and prognostic factors of pulmonary metastatic bone and sotf tissue sarcoma patients.Methods From January 2007 to December 2015, patients with bone and sotf tissue sarcoma who underwent multimodality therapy including deifnitive surgery for the primary lesion and at least one pulmonary metastasectomy were enrolled in the retrospective study. All the relevant clinical variables were collected, and then statistically analyzed and interpreted with the aid of univariate and multivariateCox proportional hazard regression method. ResultsTotally 155 pulmonary metastasectomies in 144 patients were analyzed. Incomplete R0 resection, a less than 1-year interval from a previous surgery, more than three detected nodules; and the summed maximum diameter of more than 45 mm for pulmonary metastases were independent prognostic indicators by multivariate analysis.Conclusion We suggest that meta-static bone and sotf tissue sarcoma patients can beneift most from aggressive surgical intervention of pulmonary metastasec-tomy. Its prognostic factors include R0 resection, a longer interval from a previous surgery, smaller total number and total size of pulmonary metastases.关键词
骨肉瘤/软组织肉瘤/转移/复发/预后Key words
Osteosarcoma/Sotf Tissue Sarcoma/Metastasis/Recurrence/Prognosis引用本文复制引用
康晓征,闫万璞,杨永波,戴亮,梁震,黄真,牛晓辉,陈克能..骨与软组织肉瘤肺转移的单中心大样本外科治疗结果及预后分析[J].中国肺癌杂志,2016,19(5):299-306,8.基金项目
本研究受国家高技术研究发展863计划（No.2015AA020403）、国家自然科学基金青年项目（No.81301748）、教育部创新团队发展计划（No. IRT13003）、北京市医院管理局临床医学发展专项经费（No.ZYLX201509）及北京市科技新星计划交叉合作课题（No.XXHZ201405）资助@@@@This study was supported by the grants from National High Technology Research and Development Program of China (No.2015AA020403) （No.2015AA020403）
National Natural Science Foundation for Young Scholars (No.81301748) （No.81301748）
Science Fund for Creative Research Groups of the National Natural Science Foundation of China (No.IRT13003) （No.IRT13003）
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (No.ZYLX201509) and Beijing New-Star Plan of Sci-ence and Technology (No.XXHZ201405)(all to Kenneng CHE) （No.ZYLX201509）
