中国感染控制杂志2016，Vol.15Issue(5)：294-298,5.DOI:10.3969/j.issn.1671-9638.2016.05.002
ICU患者分离金黄色葡萄球菌的耐药性及分子流行病学特征
Characteristics of antimicrobial resistance and molecular epidemiology of Staphylococcus aureus isolated from patients in intensive care units
摘要
Abstract
Objective To study the characteristics of antimicrobial resistance and molecular epidemiology of Staphylococcus aureus (S .aureus)in the intensive care units(ICUs)of a hospital.Methods Clinical isolates of S .aureus collected from ICUs between January and December 2014 were identified and performed antimicrobial susceptibility testing,then typed by staphylococcal protein A (spa)typing and multilocus sequence typing (MLST) methods.Results Of 160 isolates of S .aureus ,120 (75.00%)were methicillin-resistant S .aureus (MRSA). Resistance rates of MRSA to erythromycin,clindamycin,and levofloxacin were all > 80%;methicillin-sensitive S .aureus (MSSA)were sensitive to cefazolin,resistance rates to erythromycin,clindamycin,and levofloxacin were 62.50%,35.00%,and 10.00% respectively.spa typing and MLST results showed that the main types of 120 isolates of MRSA were ST239-t030,ST239-t037,and ST5-t2460,the major epidemic strains were ST239-t030 (n=105,87.50%),and were isolated from 8 ICUs;MSSA had more types,ST59-t437 were detected only from depart-ment of neurology(n =8)and department of digestive diseases(n =2),ST6-t701 ,ST398-t3625,ST398-t1793,and ST121-t2092 were isolated from departments of neurology(n=7),anesthesiology(n=5),neurosurgery(n=4),and cardiac surgery(n=4)respectively.Conclusion Isolation rate of MRSA in ICUs in this hospital is high,ST239-t030 is the main type,which prevailed in hospital;different types of MSSA have epidemic trends in various departments.关键词
重症监护病房/金黄色葡萄球菌/spa 分型/MLST/流行病学/抗药性,微生物/耐药性Key words
intensive care unit/Staphylococcus aureus/staphylococcal protein A typing/spa typing/multilocus sequence typing/MLST/epidemiology/drug resistance,microbial/drug resistance分类
医药卫生引用本文复制引用
徐修礼,周珊,白露,刘家云,马越云,郝晓柯..ICU患者分离金黄色葡萄球菌的耐药性及分子流行病学特征[J].中国感染控制杂志,2016,15(5):294-298,5.基金项目
陕西省自然科学基金资助项目 （）
