中国感染控制杂志2016，Vol.15Issue(5)：299-303,5.DOI:10.3969/j.issn.1671-9638.2016.05.003
倾向指数配比分析（PSM）：MRSA 与 MSSA 医院获得性肺炎预后比较
Comparison in prognosis of hospital-acquired pneumonia due to methicillin-resistant and methicillin-sensitive Staphylococcus aureus：analysis of propensity score matching
摘要
Abstract
Objective To study whether methicillin-resistant Staphylococcus aureus (MRSA)will increase the burden of patients with hospital-acquired pneumonia (HAP).Methods Patients with Staphylococcus aureus HAP in a hospital between January 1 ,2013 and November 31 ,2014 were selected,patients with MRSA HAP were as case group,patients with methicillin-sensitive Staphylococcus aureus (MSSA)HAP were as control group,propen-sity score matching (PSM)analysis were conducted to compare the prognosis of MRSA HAP and MSSA HAP (length of hospital stay, duration from infection to discharge, mortality, total therapeutic cost ). Results APACHE II score in case group was higher than control group before PSM was conducted,length of hos-pital stay and duration from infection to discharge were both longer than control group (40[20,94]d vs 28[21 ,53] d;19[10,46]d vs 17[8,29]d,respectively,both P <0.05).APACHE II score in case group and control group af-ter conducting PSM was not significantly different(P >0.05 ),data were balanced and comparable;there were no significant difference in length of hospital stay between two groups (28[21 ,52]d vs 28[21 ,53]d),duration from in-fection to discharge (15[9,25]d vs17[8,29]d),mortality(10.87% vs 15.22%),and total therapeutic cost (121 013.5[80 747.21 ,176 200]yuan vs 119 911 .2[66 994.08,241 184.7]yuan)(all P >0.05).Conclusion APACHE II score is an important factor affecting prognosis;after balancing this factor,there is no difference in the prognosis of patients with MRSA and MSSA HAP,MRSA HAP can not increase the burden of disease.关键词
倾向指数配比分析/医院获得性肺炎/金黄色葡萄球菌/耐甲氧西林金黄色葡萄球菌/甲氧西林敏感金黄色葡萄球菌/疾病负担Key words
propensity score matching/hospital-acquired pneumonia/Staphylococcus aureus/methicillin-resis tant Staphylococcus aureus/methicillin-sensitive Staphylococcus aureus/disease burden分类
医药卫生引用本文复制引用
陈文森,李松琴,李慧芬,张苏明,刘波,张翔,许平,张卫红..倾向指数配比分析（PSM）：MRSA 与 MSSA 医院获得性肺炎预后比较[J].中国感染控制杂志,2016,15(5):299-303,5.基金项目
江苏省卫生厅预防医学课题（Y2012046）；江苏高校优势学科建设工程资助项目 （）
