中国药房2016，Vol.27Issue(15)：2083-2086,4.DOI:10.6039/j.issn.1001-0408.2016.15.23
替格瑞洛对比普拉格雷对血小板反应性影响的Meta分析
Effect of Ticagrelor versus Prasugrel on Platelet Reactivity:A Meta-analysis
吴禹蒙 1程荔春 2梁晶 1刘利龙 1孙向菊 1宋佳 1吴玉波1
作者信息
- 1. 哈尔滨医科大学附属第四医院药学部，哈尔滨 150001
- 2. 大连医科大学附属第二医院药学部，辽宁大连 116027
- 折叠
摘要
Abstract
OBJECTIVE:To systematically review the effect of ticagrelor versus prasugrel on platelet reactivity,and provide evi-dence-based reference for clinical treatment. METHODS:Retrieved from PubMed,CJFD and Wanfang Database,randomized con-trolled trials(RCT)about the effect of ticagrelor versus prasugrel on platelet reactivity were collected. Meta-analysis was performed by using Rev Man software after data extract and quality evaluation by Cochrane 5.1.0. RESULTS:Totally 17 RCTs were enrolled,involv-ing 2 757 patients. Results of Meta-analysis showed,regardless of Verity Now(VN)detection method [MD=15.43,95%CI(-0.39, 31.25),P=0.06] or vasodilator stimulus phosphoprotein(VASP)detection method [MD=-3.04,95%CI(-8.98,2.90),P=0.32], ticagrelor and prasugrel had the same effects on platelet reactivity under loading dose,the differences were not statistically significant;regardless of VN detection method [MD=-48.94,95%CI(-58.04,-39.84),P<0.001] or VASP detection method [MD=-14.32, 95%CI(-20.45,-8.20),P<0.001],the effects of ticagrelor were better than prasugrel on platelet reactivity under maintenance dose,the differences were statistically significant. CONCLUSIONS:At the loading dose,there was no difference between ticagrelor and prasugrel,but ticagrelor has more benefits than prasugrel under maintenance dose.关键词
替格瑞洛/普拉格雷/血小板反应性/Meta分析Key words
Ticagrelor/Prasugrel/Platelet reactivity/Meta-analysis分类
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吴禹蒙,程荔春,梁晶,刘利龙,孙向菊,宋佳,吴玉波..替格瑞洛对比普拉格雷对血小板反应性影响的Meta分析[J].中国药房,2016,27(15):2083-2086,4.
