中国药房2016，Vol.27Issue(15)：2097-2098,2099,3.DOI:10.6039/j.issn.1001-0408.2016.15.27
龙胆配方颗粒的质量标准研究
Study on the Quality Standard of Gentiana scabra Dispensing Granule
摘要
Abstract
OBJECTIVE:To establish the quality standard for Gentiana scabra dispensing granule. METHODS:TLC was ad-opted to identify G. scabra in the preparation;HPLC was adopted to determine the content of gentiopicroside in the preparation:the column was Dionex C18 with mobile phase of methanol- water(25∶75,V/V)at a flow rate of 1.0 ml/min,the detection wave-length was 270 nm,column temperature was 30 ℃,the injection volume was 10 μl. RESULTS:TLC showed clear spots and good separation. The linear range of gentiopicroside injection volume was 0.302 6-3.026 μg (r=0.999 9);RSDs of precision,stability and reproducibility tests were lower than 2%;recovery was 98.27%-99.56%(RSD=0.68%,n=6). CONCLUSIONS:The estab-lished standard can be used for the quality control of Gentiana scabra dispensing granule.关键词
龙胆/配方颗粒/薄层色谱法/高效液相色谱法/质量标准Key words
Gentiana scabra/Dispensing granule/TLC/HPLC/Quality standard分类
医药卫生引用本文复制引用
李海兵,张霞,周永妍,王正品,张岩岩,李军山,陈军霞..龙胆配方颗粒的质量标准研究[J].中国药房,2016,27(15):2097-2098,2099,3.基金项目
国家中医药管理局科技项目（No.2013X07）；河北省科技计划项目 （）
