中国药房2016，Vol.27Issue(15)：2117-2118,2119,3.DOI:10.6039/j.issn.1001-0408.2016.15.34
HPLC法测定不同厂家联苯苄唑凝胶的含量
Content Determination of Bifonazole Gel from Different Manufacturers by HPLC
钱燕媚 1伍名兰 2郑婕1
作者信息
- 1. 广州中医药大学第一附属医院，广州 510405
- 2. 广州白云山天心制药股份有限公司，广州 510300
- 折叠
摘要
Abstract
OBJECTIVE:To evaluate the quality of Bifonazole Gel from different manufacturers. METHODS:HPLC was per-formed on the column of Diamonsil C18 with mobile phase of methanol- water- tetrahydrofuran(75∶24∶1,V/V/V)at a flow rate of 1.0 ml/min,detection wavelength was 254 nm,column temperature was 23 ℃,and the injection volume was 10 μl. RESULTS:The linear range of bifonazole was 50-600 μg/ml (r=0.999 9);RSDs of precision,stability and reproducibility tests were lower than 1%;recovery was 97.71%-101.68%(RSD=1.16%,n=9). The contents of Bifonazole gel samples from 3 manufacturers were more than 10 mg/g,with little difference. CONCLUSIONS:The method is simple and accurate with good separation and re-producibility,and suitable for the content determination of Bifonazole gel. The investigated contents of products from different man-ufactures conform to relevant standards.关键词
联苯苄唑凝胶/高效液相色谱法/含量测定/市售产品/质量Key words
Bifonazole gel/HPLC/Content determination/Commercially available products/Quality分类
医药卫生引用本文复制引用
钱燕媚,伍名兰,郑婕..HPLC法测定不同厂家联苯苄唑凝胶的含量[J].中国药房,2016,27(15):2117-2118,2119,3.
