中国药房2016，Vol.27Issue(16)：2276-2278,3.DOI:10.6039/j.issn.1001-0408.2016.16.34
星点设计-响应面法优化补肾活血胶囊提取工艺
Optimization of the Extraction Technology of Bushen Huoxue Capsules by Central Composite Design-re-sponse Surface Method
殷佳 1殷健 2朱艳 2邢冰琪 1傅春升1
作者信息
- 1. 山东中医药大学附属医院，济南 250014
- 2. 山东鲁南监狱医 院，山东日照 277605
- 折叠
摘要
Abstract
OBJECTIVE:To optimize the extraction technology of Bushen huoxue capsules. METHODS:Central composite de-sign-response surface method was used to optimize the extraction technology with the amount of water and boiling time as main fac-tors using normalized value of the contents of icariin and salvianolic acid B,the yield of dry extract as index. Validation test was al-so conducted. RESULTS:The optimal extraction technology was as follows as 15-fold water,reflux extracting for 75 min,extract-ing for 2 times. The deviation of measured value and predicted value was 0.000 3% in validation test. CONCLUSIONS:The cen-tral composite design-response surface method can be used to optimize the extraction technology of Bushen huoxue capsules with good prediction,and the technology is simple and stable.关键词
补肾活血胶囊/星点设计-响应面法/提取工艺/淫羊藿苷/丹酚酸BKey words
Bushen huoxue capsules/Central composite design-response surface method/Extraction technology/Icariin/Salvi-anolic acid B分类
医药卫生引用本文复制引用
殷佳,殷健,朱艳,邢冰琪,傅春升..星点设计-响应面法优化补肾活血胶囊提取工艺[J].中国药房,2016,27(16):2276-2278,3.
