中国药理学与毒理学杂志2016，Vol.30Issue(5)：498-503,6.DOI:10.3867/j.issn.1000-3002.2016.05.003
盐酸阿姆西汀对行为绝望模型和单胺递质耗竭模型小鼠的抗抑郁作用
Antidepressant-like effects of ammoxetine in mice of behavioral despair model and monoamine neurotransmitter depletion model
摘要
Abstract
OBJECTIVE To study the antidepressant effects of ammoxetine(AMX)and the underlying mechanisms. METHODS Two behavioral despair models,the tail suspension test (TST) and the forced swimming test(FST),were used to evaluate the antidepressant-like effects of AMX 2.5-20 mg · kg-1 following oral administration. Monoamine neurotransmitter p-chloro-phenylalanine(p-CPA)andα-methyl-p-tyrosine(AMPT) depletion models in mice were used to investigate the effects of AMX on levels of 5-serotomin(5-HT)and norepinephrine(NE)in the brain. RESULLTS The results of behavioral study showed that compared with normal control group,AMX(10 and 20 mg · kg-1)reduced the immobility time of mice by 51.4% and 80.7% in the TST(P<0.05,P<0.01) or by 48.0% and 66.2% in the FST (P<0.05),respectively. Locomotion activity test indicated that AMX did not increase or decrease the movement distance of mice,demonstrating that AMX had no excitatory or inhibitory actions on the central nervous system. Moreover,AMX(5,10 and 20 mg·kg-1)exerted antidepressant effects in the p-CPA induced 5-HT depletion model and AMPT induced NE depletion model,as evidenced by the significantly reduced immobility time,ie,63.9%,93.4%,90.5% and 61.9%,77.2%,100% reduction in the TST (P<0.01),respectively,and AMX at the dose of 20 mg·kg-1 significantly increased the concentrations of 5-HT and NE by 144.7% and 57.2% in the mouse brain(P<0.05) ,respectively. CONCLUSION AMX has strong antidepressant-like effects in behavioral despair models and monoamine neurotransmitter depletion models in mice,which is involved in the increased levels of 5-HT and NE in the brain.关键词
阿姆西汀/抗抑郁药/行为绝望模型/单胺神经递质耗竭模型Key words
ammoxetine/antidepressive agents/behavioral despair model/monoamine neurotransmitter depletion model分类
医药卫生引用本文复制引用
郭岩,薛瑞,张亭亭,范琼尹,李云峰,仲伯华,张有志..盐酸阿姆西汀对行为绝望模型和单胺递质耗竭模型小鼠的抗抑郁作用[J].中国药理学与毒理学杂志,2016,30(5):498-503,6.基金项目
国家科技重大专项（2012-ZX09102101-004）；国家自然科学基金（81302761）；国家自然科学基金 （）
