中国药理学与毒理学杂志2016，Vol.30Issue(5)：588-597,10.DOI:10.3867/j.issn.1000-3002.2016.05.017
抗氧化剂与延长寿命的相关性研究进展
Research progress in correlations between antioxidants and lifespan extension
摘要
Abstract
Oxidative damage theory is currently one of the predominant theories on the mechanisms of aging. Previous research has shown that antioxidants can extend the lifespan in the model organism by scavenging free radicals,inducing the expression of stress related genes and hormesis. However, recent studies have suggested that these pharmaceuticals may cause serious side effects,such as promoting oxidation,increasing the risk of cancer,and destroying the metabolic balance. The low absorption and targeting property also limit the efficiency of most antioxidants. As a result ,the correlation between antioxidants and lifespan extension remains to be demonstrated. We reviewed the research progress in the field of lifespan extension by antioxidants in recent years and provided references for future research in related areas.关键词
抗氧化剂/寿命/衰老/活性氧类/氧化损伤Key words
antioxidants/lifespan/aging/reactive oxygen species/oxidative damage分类
医药卫生引用本文复制引用
吴奇,朱晨星,樊晓兰,杨德英,杨明耀..抗氧化剂与延长寿命的相关性研究进展[J].中国药理学与毒理学杂志,2016,30(5):588-597,10.基金项目
国家自然科学基金（31471998）；四川农业大学创新团队（03571569）；四川省千人计划 （）
