中国医学创新2016，Vol.13Issue(14)：7-10,4.DOI:10.3969/j.issn.1674-4985.2016.14.002
Survivin基因多态性与结直肠癌发病风险的相关性分析
Analysis on Association of Survivin Gene Polymorphisms with the Risk of Colorectal Cancer
摘要
Abstract
Objective:To investigate the association of Survivin gene polymorphisms with the risk of colorectal cancer.Method:From January 2013 to May 2015,186 cases of rectal cancer in our hospital were selected as the research group and 194 cases of healthy persons were selected as control group at the same time. They were collected peripheral blood and extract DNA by using proteinase K digestion and saturated sodium chloride salting out method,and polymerase chain reaction (PCR),ligase detection reaction (LDR) were used for rs9904341C/G polymorphism genotyping,the genotyping results in two groups were compared.Result:The C/C gene frequency was 44.62% in the research group,higher than 28.35% of the control group,C/G gene frequency was 39.78%,lower than 49.48% of the control group,the differences were statistically significant(P<0.05). The G/G gene frequency was 15.59%,lower than 22.16% of the control group,the difference was not statistically significant(P>0.05).Compared with the control group,in the research group,theOR value of Survivin C/G gene was 0.764(0.54-1.04)(P=0.020),theOR value of Survivin C/C gene was 1.376(0.91-2.07)(P=0.031),the OR value of Survivin G/G gene was 1.004(0.84-1.13)(P=0.121).The risk of colorectal cancer was reduced in the group with C/G gene,while was elevated in the group with C/C gene.Conclusion:Survivin gene polymorphism and risk of colorectal cancer have a higher relevance,for the diagnosis of colorectal cancer and explore the target miRNA polymorphism as a symbol of individual identification of colorectal cancer risk and its mechanism to provide theoretical and experimental basis,also means that finding and screening miRNA polymorphism closely related to the risk of cancer is expected to become the effective way of system for the study of tumor early diagnosis and pathogenic mechanism,so it has great practical value and broad application prospect.关键词
Survivin基因多态性/结直肠癌/发病风险Key words
Survivin gene polymorphism/Colorectal cancer/Risk of disease引用本文复制引用
王健..Survivin基因多态性与结直肠癌发病风险的相关性分析[J].中国医学创新,2016,13(14):7-10,4.基金项目
江西省卫生计生委科技计划项目 （）
