中国医学创新2016，Vol.13Issue(14)：20-23,4.DOI:10.3969/j.issn.1674-4985.2016.14.005
PCOS患者雄激素受体基因和性激素结合蛋白基因情况观察
Observation of Androgen Receptor Gene and Sex Hormone Binding Protein Gene in PCOS Patients
摘要
Abstract
Objective:To investigate the status of androgen receptor gene and sex hormone binding protein gene in patients with polycystic ovary syndrome(PCOS).Method:A total of 62 PCOS patients were selected as the observation group from November 2014 to July 2015 in our hospital,the control group were choosed from the same period due to the occurrence of reproductive system abnormalities lead to infertility in 62 patients.DNA gene amplification,agarose gel electrophoresis and capillary electrophoresis were performed to detect the expression of androgen receptor and sex hormone binding protein gene in PCOS patients.Result:SHBG-TAAAA gene type of polymorphic and insulin resistance of the observation group in the study,found that 9/9 genotype distribution in insulin resistance and insulin resistance had a significant difference in two groups(P<0.05).In the observation group,the distribution of short repeating group in high androgen blood group was 52.94%,and in normal androgen group was 42.86%,respectively.The distribution of long repetitive group in hyperandrogenemia group was 61.76%, in the distribution of normal androgen group was 39.29%,two group’s data had significant differences(P<0.05). Conclusion:Androgen receptor gene and sex hormone binding protein gene is associated with polycystic ovary syndrome (PCOS),which may be an important role in the detection of PCOS,PCOS prevention and treatment, and early diagnosis of polycystic ovary syndrome.关键词
多囊卵巢综合征/雄激素受体基因/性激素结合蛋白基因Key words
Polycystic ovary syndrome/Androgen receptor gene/Sex hormone binding protein gene引用本文复制引用
马娟,周俊,田贵聪,石华..PCOS患者雄激素受体基因和性激素结合蛋白基因情况观察[J].中国医学创新,2016,13(14):20-23,4.基金项目
广东省医学科学技术研究基金项目 （）
