中国医学创新2016，Vol.13Issue(14)：137-139,140,4.DOI:10.3969/j.issn.1674-4985.2016.14.036
骨钙素调节糖代谢的研究进展
Research Progress in Regulation of Glucose Metabolism by Osteocalcin
种珍珍 1胡玲2
作者信息
- 1. 山西医科大学 山西 太原 030001
- 2. 山西医科大学附属人民医院
- 折叠
摘要
Abstract
Osteocalcin(OC) is a bone matrix proteins,which is synthesized and secreted by osteoblasts, it is regularly used as the serum marker in the clinical setting.Recent evidence indicated that OC,especially ucOC, can regulate the glucose metabolism by promoting the proliferation of B-cell,enhancing the secretion of insulin and improving the sensitivity of insulin.GPRC6A is the receptor of osteocalcin which expressed in pancreatic islets, while the enterococcal surface protein(ESP) gene and insulin signal can regulate the glucose metabolism through regulate the bioactivity of OC.Clinical observations also confirmed the regulating effect of OC.OC may be a new therapeutic target for the treatment of diabetes and obesity in the future.关键词
骨钙素/羧化不全骨钙素/葡萄糖代谢Key words
Osteocalcin/Undercarboxylated osteocalcin/Glucose metabolism引用本文复制引用
种珍珍,胡玲..骨钙素调节糖代谢的研究进展[J].中国医学创新,2016,13(14):137-139,140,4.
