中国医学创新2016，Vol.13Issue(15)：55-58,4.DOI:10.3969/j.issn.1674-4985.2016.15.017
帕金森病冻结步态患者血清尿酸水平变化及意义
Level and Value of Serum Uric Acid in PD Patients with FOG
武兵 1庞家秉2
作者信息
- 1. 内蒙古国际蒙医医院 内蒙古 呼和浩特 010065
- 2. 呼和浩特市第一医院
- 折叠
摘要
Abstract
Objective:To investigate the level and value of serum uric acid(UA) in patients with Parkinson’s disease(PD) with freezing of gait(FOG).Method:One hundred and eighty-five PD patients were selected as PD with FOG group and PD without FOG group,and one hundred and one age and sex-matched healthy controls as the control group.The serum UA and creatinine concentrations were measured and carefully analyzed. By comparing the UA concentrations of PD with FOG group and PD without FOG group with their counterparts in the control group,we obtained the differences among these three groups and also discussed possible reasons and factors.Result:The serum UA levels of patients with FOG[(261.37±57.23)μmol/L] were significantly lower than that[(288.64±61.27)μmol/L,P=0.037] PD without FOG and the control group[(331.45±59.25)μmol/L,P=0.001]. And the serum UA levels of patients without FOG were significantly lower than the controls(P=0.001).Thedifference of endogenous creatinine clearance among these three groups did not reach statistical significance (P>0.05).Conclusion:The serum UA level of PD patients are closely associated with FOG since the levels are significantly decreased in patients with FOG.The UA,as an antioxidant,may be beneficial to the neurodegenerative diseases.关键词
冻结步态/帕金森病/尿酸Key words
Freezing of gait/Parkinson’s disease/Uric acid引用本文复制引用
武兵,庞家秉..帕金森病冻结步态患者血清尿酸水平变化及意义[J].中国医学创新,2016,13(15):55-58,4.
