中国医学创新2016，Vol.13Issue(16)：9-12,4.DOI:10.3969/j.issn.1674-4985.2016.16.003
靶向治疗对早期非小细胞肺癌的生存质量的队列研究
Targeting Therapy of Early Stage Non Small Cell Lung Cancer Patients Life Quality and Immune Function of Influence
摘要
Abstract
Objective:To observe the targeting therapy of early stage non small cell lung cancer (NSCLC) affect the life quality and immune function of patients.Method:126 patients with early non small cell lung cancer in our hospital from June 2014 to May 2016 were selected as the objects of study,they were randomly divided into molecular targe group of 76 cases and conventional treatment group of 50 cases.The molecular targe group was given drug therapy for the treatment,the dose for Gefitinib Imatinib 250 mg/d,Erlotinib Erlotinib 150 mg/d, ALK positive detection by Eck for Nigerian 125 mg/time,3 times a day,continuous treatment for 12 months. The conventional treatment group was given adjuvant chemotherapy. of therapeutic effect, quality of life, immune function and adverse reactions of two groups were observed.Result:The total effective rate and disease control rate of two groups had no significant difference(P>0.05); there were statistically significant differences of KPS score in molecular target group before and after treatment(P<0.05),after treatment,the KPS score of two groups had statistically significant difference(P<0.05);the quality life of two groups after treatment had statistically significant difference(P<0.05),and molecular targeted group of that was better than control group, the difference was statistically significant(P<0.05).The main adverse reactions were rash, diarrhea, nausea and ulcers,but it had no effect on anti tumor therapy.Conclusion:The targeted therapy for early stage non-small cell lung cancer patients can improve the life quality and immune function of patients.关键词
靶向治疗/早期非小细胞肺癌/生活质量/机体/影响Key words
Targeted therapy/Non small cell lung cancer/Quality of life/Body/Influence引用本文复制引用
温泳涛,赵一菊,王兆邦,谢衬梨,颜建辉,张文娟,梁秋亭..靶向治疗对早期非小细胞肺癌的生存质量的队列研究[J].中国医学创新,2016,13(16):9-12,4.基金项目
广东省东莞市科技计划医疗卫生类科研项目 （）
