中国医学创新2016，Vol.13Issue(16)：17-20,4.DOI:10.3969/j.issn.1674-4985.2016.16.005
不同剂量维生素D加钙防治围绝经期妇女骨质疏松症的安全性研究
Clinical Efficacy and Safety of Different Doses of Vitamin D with Calcium Used in Treatment of Female Perimenopausal Osteoporosis
摘要
Abstract
Objective:To compare the clinical efficacy and safety of different doses of vitamin D with calcium used in treatment of female perimenopausal osteoporosis.Method:91 perimenopausal women who were diagnosed as osteopenia or osteoporosis by bone mineral density(BMD) test were selected from January 2015 to March 2016,they were randomly divided into 3 groups, low dose group of 30 cases were given vitamin D 250 IU+calcium 1200 mg,medium dose group of 31 cases were given vitamin D 450 IU+calcium 1281 mg, high dose group of 30 cases were given vitamin D 850 IU+calcium 1443 mg,they were orally taken respectively daily for 6 months.The pain changes,BMD and bone biochemical determinations before and after each intervention were observed and measured.Result:After 6 months treatment,the total efficiency in high dose group was higher than that in the low dose group,BMD and the level of 25(OH)D in high and medium dose group were increased compared with before treatment,whereas the level of B-ALP decrease significantly,the differences were statistically significant(P<0.05).Conclusion:Vitamin D supplementation with calcium in medium dose group and high dose group have better efficacy and high safety in treatment of female perimenopausal osteoporosis, which can improve the bone symptoms,increase the BMD and the level of vitamin D in the body,it gives a guidance for clinical treatment.关键词
维生素D/围绝经期/骨质疏松症/钙剂/安全有效摄入量Key words
Vitamin D/Perimenopause/Osteoporosis/Calcium/Safe and effective intake引用本文复制引用
李鸿霞,冷思宏,张光辉,朱翠凤,周见昕,陈李桃,叶悦坤,雷莉..不同剂量维生素D加钙防治围绝经期妇女骨质疏松症的安全性研究[J].中国医学创新,2016,13(16):17-20,4.基金项目
广东省深圳市宝安区2015年科技计划项目 （）
