中国医学创新2016，Vol.13Issue(16)：139-141,3.DOI:10.3969/j.issn.1674-4985.2016.16.039
sEphB4抑制视网膜新生血管和玻璃体增殖的研究
The Study of sEphB4 Inhibition on Retinal Neovascularization and Vitreous Proliferation
摘要
Abstract
Objective:To investigate the effect of sEphB4 on inhibiting the proliferation of retinal neovascularization and vitreous proliferation.Method:The long term DR rabbit eye model was established,the right eyes of all DR rabbits were treated as drug intervention which 50 μL sEphB4 was injected into the vitreous cavity,the dose of sEphB4 was respectively 1000,465,160 and 80 μg.Left eyes as the control eyes,they were given the physiological saline 50μL vitreous cavity injection. This intervention treatment lasted 6 months,1 time a month injection.The changes of OCT and ERG before and after the intervention of two groups were compared. Result:The FFA leakage of the diabetic rabbit model reduced,diabetic model of OCT thickened,after the intervention becomes thin and with dose increasing negative correlation,with the increase of concentration, measured by OCT retinal thickness of the thinner closer to normal thickness.Diabetic rabbit model of ERG aA values gradually decreased with the increase of the dose,after the intervention of gradually close to normal value, and is positively correlated with the dose.Conclusion:sEphB4 can inhibit the retinal edema in rabbit model of diabetic retinopathy,and improve the function of the retina.关键词
sEphB4抑制/视网膜/新生血管/玻璃体增殖Key words
sEphB4 inhibition/Retina/Neovascularization/Vitreous proliferation引用本文复制引用
颜坚,姜文浩,彭细峰,黎颖莉..sEphB4抑制视网膜新生血管和玻璃体增殖的研究[J].中国医学创新,2016,13(16):139-141,3.基金项目
深圳市科技研发资金资助项目 （）
