中国医学前沿杂志（电子版）2016，Vol.8Issue(4)：22-25,4.
普瑞巴林治疗脑卒中后中枢性疼痛的临床分析
Effcacy of pregabalin in the treatment of central post-stroke pain
摘要
Abstract
ObjectiveTo evaluate the therapeutic effects of pregabalin on central post-stroke pain (CPSP) patients.Method83 patients with CPSP admitted in Shaanxi Provincial People's Hospital were randomly divided into standard treatment plus pregabalin group (n=42) and standard treatment control group (n=41). At baseline, 2 weeks after treatment and 1 month after treatment, pain intensity changes were assessed by numerical rating score (NRS); mood changes were assessed by 17-item Hamilton depression scale (HAMD-17) and the Hamilton anxiety scale (HAMA). Adverse reactions were recorded.ResultNRS scores were gradually decreased at 2 weeks after treatment and at 1 month after treatment compared with baseline. The decrease in NRS was more significant in pregabalin group than control group (P<0.05 andP<0.01, respectively). No obvious change of HAMD-17 and HAMA was found in the two groups 2 weeks after treatment. The HAMD-17 and HAMA scores at 1 month after treatment were significantly lower in pregabalin group than control group (P<0.05). Fewer transient adverse reactions were found in pregabalin group.ConclusionPregabalin is effective in relieving pain and mood disturbance in CPSP patients with sound safety.关键词
脑卒中/中枢性疼痛/普瑞巴林Key words
Stroke/Central pain/Pregabalin引用本文复制引用
唐鹏,赵素平,李晓青,王逍,刘玥,种莉,李锐..普瑞巴林治疗脑卒中后中枢性疼痛的临床分析[J].中国医学前沿杂志（电子版）,2016,8(4):22-25,4.基金项目
陕西省重点科技创新团队项目 （）
