摘要
Abstract
ObjectiveTo study the impact of statin therapy on the survival status of elderly patients with coronary heart disease (CHD) before percutaneous coronary intervention (PCI).Method120 elderly patients with coronary heart disease were chosed in our hospital from February 2014 to 2015 January were divided into 20 mg statin group and 40 mg statin group according to a random number table method, 60 cases in each group. 20 mg statin group was given atorvastatin calcium 20 mg, 30 minutes before PCI. 40 mg statin group was given atorvastatin calcium 40 mg, 30 minutes before PCI. The levels of creatine kinase isoenzyme MB (CK-MB) and cardiac troponin I (cTnI) and high sensitive C reactive protein (hs-CRP) were detected before PCI and 12, 24 hours after PCI. The levels of alanine aminotransferase (ALT) were detected before PCI and 24 hours after PCI. The major cardiac adverse events (MACE), included cardiac death, myocardial infarction, repeat target blood vessel revascularization were observed within 30 days after PCI.ResultThe CK-MB and cTnI levels after operation for 24 hours of the two groups were significantly increased compared with before PCI (P<0.05), the hs-CRP levels after operation 24 hours were significantly increased compared with before PCI (P<0.05). The CK-MB, cTnI, hs-CRP levels of 40 mg statin group was significantly lower than 20 mg statin group (P<0.05); after operation 24 hours, the ALT level of 40 mg statin group was significantly increased compared with before PCI (P<0.05), but the average level was stillwithin the normal range. The total cardioascular events rate of 20 mg statin group within 30 days after PCI was significantly higher than 40 mg statin group (P<0.05).ConclusionThe statin therapy before PCI can improve bloodflow perfusion in elderly patients with coronary heart disease, and reduce acute coronary events, and can be recommended conventional medicine for elderly patients with CHD before PCI.关键词
他汀类药物/冠心病/经皮冠状动脉介入治疗/生存状况Key words
Statins/Coronary heart disease/Percutaneous coronary intervention/Survival condition
