摘要
Abstract
ObjectiveTo analyze the effect of salmeterolfluticasone propionate on pulmonary function and the level of serum inflammatory factors in elderly patients with chronic obstructive pulmonary disease (COPD) in acute stage.MethodChosed 66 cases of patients suffered from COPD with acute episode in our hospital from March 2014 to March 2015. They were divided into control group and treatment group according to the random number table method, 33 cases in each group. Two groups of patients were given conventional basic treatment, control group patients were given oral sustained-release theophylline capsules, used ambroxol hydrochloride tablets adjuvant therapy when necessary. Treatment group patients on the basis of control group treatment with intake salmeterolfluticasone propionate inhalation, two groups patients course of treatment was 6 months. Compared the pulmonary function index, clinical efficacy, serum inflammatory factor levels and adverse reactions of two groups of patients before and after treatment.ResultAfter treatment, thefirst second forced expiratory volume (FEV1), forced expiratory volume in thefirst second (FEV1/FVC), forced vital capacity (FVC) were higher than before treatment (P<0.05), and treatment group of patients with FEV1, FEV1/FVC, FVC were higher than control group (P<0.05). The total effective rate of treatment group was significantly higher than control group (χ2=5.790,P<0.05). After treatment, interleukin (IL)-8, tumor necrosis factor-α (TNF-α), C reactive protein (CRP) levels of two groups were lower than before treatment (P<0.05), the levels of IL-8, TNF-α and CRP of treatment group were significantly lower than control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (χ2=0.216,P>0.05).ConclusionElderly patients with chronic obstructive pulmonary disease and during acute time treat with salmeterol andfluticasone propionate have exactly curative effect,and it can effectively improve the lung function and reduce the levels of serum CRP, IL-8 and TNF-α, have no obvious adverse reaction, it is worth popularizing and applying.关键词
沙美特罗替卡松/慢性阻塞性肺疾病/肺功能/肿瘤坏死因子-αKey words
Salmeterolfluticasone/Chronic obstructive pulmonary disease/Pulmonary function/TNF-α
