摘要
Abstract
Objective To optimize water extract - alcohol extraction method of Majiezhike Granules. Methods The content of ephedrine hydrochloride was examined by orthogonal design, and the influence of the extraction times, extraction duration and consumption of wa-ter on the extraction process by water were observed;the retention rate of ephedrine hydrochloride and decrement of solid mater were examined, and the influence of relative density of medication, concentration of alcohol and alcohol extraction duration on the extraction procedure by alcohol were observed. Results The best optimizations of water extract-alcohol extraction were the weight of water was 10 times, boiled 3 times, the first time 60 min, the second and the last time 40 min;then the extract was concentrated to a relative density of 1. 20, after it was cooled, added alcohol to make the alcohol content being 80%; placed for 24 h, removed precipitate. Conclusion The optimized method of water extract-alcohol extraction is stable, feasible, reproducible and is suitable for industrial production.关键词
麻桔止咳颗粒/正交试验/盐酸麻黄碱/工艺优选Key words
Majiezhike Granules/orthogonal experiment/ephedrine hydrochloride/process optimization分类
化学化工
