摘要
Abstract
Objective To analyze the influence of metformin combined with strengthening lifestyle intervention on serum high sensitive C-reactive protein and insulin sensitive index. Methods 134 cases of patients with type 2 diabetes mellitus in March 2013 to March 2014 in the Endocrine Department of the hospital were divided into observation group and control group according to the number table methods, the observation group of patients was given diet control, strict dietary energy restriction and with the laws of motion, to change their bad life style and taking metformin for treatment. The control group was treated with metformin tablets only. For 2 months of inter-vention, the effect of anti diabetes treatment for the two groups and the changes of the indicators before and after the intervention were observed. Results After intervention, the clinical effect of the observation group was significantly better than that of the control group, the difference was statistically significant ( P < 0. 05 ) . After the intervention, the BMI, hs CRP and blood glucose levels ( FBG, 2hbg, HbA1c, HOMA-IR, fins and ISI ) and lipid levels ( TG, TC, HDL-C and LDL-C ) of the observation group were significantly better than the control group ( P < 0. 05 ) . Conclusion Lifestyle intervention can significantly decreased weight index and blood glucose levels in aged patients with type 2 diabetes, improve lipid metabolism, reduce insulin resistance and restore insulin sensitivity.关键词
2型糖尿病/生活方式干预/二甲双胍/血清超敏C反应蛋白/胰岛素敏感指数Key words
type 2 diabetes mellitus/lifestyle intervention/metformin/serum high-sensitivity C reactive protein/insulin sensitivity index分类
医药卫生
