中国药业2016，Vol.25Issue(9)：12-14,3.
壳聚糖修饰托氟啶纳米脂质体的体外释放试验研究
In Vitro Drug Release Test of Chitosan Modified TFu-SLNs
杨海 1马宝花 1周学锋1
作者信息
- 1. 山东省青岛市中心医院，山东 青岛 266042
- 折叠
摘要
Abstract
Objective To study the in vitro drug release of chitosan modified N3-O-toluyl-flulorouracil ( TFu ) Solid Lipid Nanoparti-cles ( SLNs ) . Methods The released kinetics of chitosan modified TFu-SLNs in vitro of different media, such as the phosphate buffer solution ( pH=7. 4 ) , artificial gastric juice ( pH=1. 2 ) , artificial intestinal juice ( pH=6. 8 ) , and artificial gastric juice followed by aritifical intestinal juice, were studied by dynamic dialysis system using TFu solution as control. The recovery rate of the method was determi-nated in different media. Results In case of solution, all the release profiles of TFu could be described by first order kinetics model and could be expressed by the following equations: A=37 602 C+160. 48 ( r=0. 999 9 ) , A=39 488 C+1 915. 3 ( r=0. 999 8 ) , A=38 790 C-194. 11 ( r=0. 999 3 ) , respectively. In artificial gastric juice, the in vitro release behavior of chitosan modified TFu-SLNs could be expressed by the Ritger-Peppas equations:lnQ=0. 398 4 ln t+3. 135 2 ( r=0. 979 6 ) . In artificial intestinal juice and artificial gastric juice followed by aritifical intestinal juice, the TFu release behavior of chitosan modified TFu-SLNs in vitro were both in accord with Weibull model: ln Q=0. 385 2 ln t-1. 325 86 ( r=0. 964 5 ) ln Q=0. 412 6 ln t-1. 270 2 ( r=0. 974 6 ) . Conclusion Chitosan Modified TFu-SLNs can release the drug slowly, and the drug release mechanism is dominated by drug diffusion.关键词
托氟啶/壳聚糖/体外释放度Key words
N3-O-toluyl-flulorouracil ( TFu )/chitosan/invitro release分类
医药卫生引用本文复制引用
杨海,马宝花,周学锋..壳聚糖修饰托氟啶纳米脂质体的体外释放试验研究[J].中国药业,2016,25(9):12-14,3.
