摘要
Abstract
Objective To study the stimulation effect of Qingkailing Inhalation on SD rats' mouth, nose, trachea and lung. Methods 12 Wistar rats were randomly divided into 3 groups, namely the control group ( saline ) , Qingkailing low concentration group ( 1 : 10 ) and Qingkailing high concentration group ( 1:1 ) , for a 7 d atomization inhalation experiment and the behavior of rats after each administra-tion was observed. On the 8th day, the oral mucosa, nasal septum mucosa, trachea, left lung, paraffin sections were prepared to observe the structural changes of the morphology. The right alveolar lavage was performed at the 8th day, and the lavage fluid protein and LDH activity were measured. Results There was an obvious damage in the mouth, nose, trachea and lung in the high and low concentration groups, and the damage in the high concentration group was significantly higher than that in low concentration group. There was no significant difference between the BCA protein in the bronchoalveolar lavage fluid in the 3 groups. LDH activity assay showed significant differences between the two Qingkailing groups and the control group, and showed a positive correlation. Conclusion Qingkailing atom-ization inhalation has stimulation effect on rats' mouth, nose, trachea and lung, and high concentration of atomization can cause huge tissue damage of the respiratory mucosa.关键词
清开灵/雾化吸入/病理切片/肺泡灌洗/刺激性Key words
Qingkailing/inhalation/pathological section/alveolar lavage/stimulation分类
医药卫生
