摘要
Abstract
Objective To observe the clinical efficacy of caspofungin combined with voriconazole in treating invasive fungal infection of secondary malignant blood disease, and to summarize the nursing points. Methods 52 cases of patients with malignant hematological diseases complicated with fungal infection from January 2012 to April 2015 were randomly divided into observation group and control group, 26 cases in each group. The control group was treated with itraconazole, the observation group was added with caspofungin. The two groups were given corresponding nursing. After 10 weeks of treatment, the clinical efficacy of the two groups were compared, the blood bacterial and fungal cultures, the IFN - gamma and IL-10 expression levels were tested before and after the treatment, the occurrence rate of adverse reactions were recorded. Results After treatment, the total effective rate of the observation group was 89. 46%, which was significantly higher than 73. 08% in the control group ( P < 0. 05 ) . Compared with before treatment, the ratios of candida, aspergillus, cryptococcus and other fungal distribution in the observation group were decreased ( P < 0. 05 ) , and the ratios of candida and aspergillus distribution decreased in the control group ( P < 0. 05 ); the ratios of candida and aspergillus distribution of the observation group were significantly lower than the control group with statistical significance ( P < 0. 05 ) . After treatment, the IFN - gamma /IL-10 ratio of the two groups increased, and the observation group increased more than the control group, the difference was statistically significant ( P < 0. 05 ) . The incidence rates of skin rash, nausea and aminotransferase increased in the observation group had no statistically significant difference with the control group ( P > 0. 05 ); the incidence of visual abnormality was 7. 69% in the observation group, which was higher than the control group, the difference was statistically significant ( P < 0. 05 ) . Conclusion Caspofungin combined with voriconazole for invasive fungal infection of malignant blood disease secondary has better clinical efficacy, can improve the clearance rate of candida and aspergillus, improve the patients' immune;proper nursing care can enhance the compliance of patients, which is worthy of clinical promotion.关键词
卡泊芬净/伏立康唑/恶性血液病/侵袭性真菌感染/临床疗效Key words
caspofungin/voriconazole/malignant blood disease/invasive fungal infection/clinical efficacy分类
医药卫生
