蒙光义 1潘鹏 2王冬晓 2彭评志 1庞家莲 1邹超世1
作者信息
- 1. 广西壮族自治区玉林市第一人民医院，广西 玉林 537000
- 2. 广西壮族自治区玉林市妇幼保健院，广西 玉林 537001
- 折叠
摘要
Abstract
Objective To investigate the distribution and drug resistance of common pathogens, to provide guidance for reasonable clinical use of antibiotics and control nosocomial infections. Methods Specimens were collected and indentified from 2013 to 2014 in hospitali-zed patients with various clinical departments. The bacterial identification was indentified and performed by VITEK-2 Compact of Biomeriex, France, then the drug susceptibility testing was performed, and the data were analyzed by WHONET 5. 5 software. Results A total of 9 149 strains of pathogens were isolated from 2013-2014, among which the gram-negative bacteria were 6 647 strains, ac-counting for 72. 65%, of which, and the top 4 pathogens in order were escherichia coli, klebsiella pneumonia, pseudomonas aeruginosa and acinetobacter baumannii; gram-positive bacterium were 2 502 strains, accounting for 27. 35%, and the top 4 pathogens in order were staphylococcus aureus, streptococcus pneumoniae, enterococcus faecalis, staphylococcus haemolyticus. The drug resistance rate of escherichia coli and klebsiella pneumonia to cefazolin, ceftriaxone and trimethoprim/sulfamethoxazole were more than 50%;the drug re-sistance rate of hemophilus influenzae to ampicillin, levofloxacin and rimethoprim/sulfamethoxazole were 61. 45% , 60. 24% and 74. 70%, respectively; the drug resistance rate of enterobacter cloacae to ceftriaxone and aztreonam were 58. 90% and 50. 92%. The main gram-negative bacilli were especially sensitive to amikacin, imipenem, meropenem, cefotetan, cefoxitin, cefoperazone/sulbactam, and the drug resistance rate were more less 20%; the drug resistance rate of the main non-fermentataive bacterial to acinetobacter bau-mannii to common antibacterial drugs were high. The drug resistance rate of the main gram-positive bacteria in addition to vancomycin and linzolid were 0, and had different degrees of drug resistance rate to common antibacterial drugs, among which to penicillin was more than 45%, and to erythrocin were more than 65%. The drug resistance rate of enterococcus faecium and enterococcus faecalis to van-comycin were 2. 78% and 1. 15%, and to linezolid were 2. 78% and 11. 06%, but the drug resistance rate of enterococcus faecium and enterococcus faecalis to common antibacterial drugs were high. Conclusion Pathogenic bacteria are the main gram-negative bacilli in clinic, and they have drug resistance rate to common antibacterial, thus drug resistance monitoring should be strengthened in order to in-struct rational use of antibiotics.关键词
医院感染/病原菌/抗菌药物/耐药性/合理用药Key words
hospital infections/pathogen/antibiotics/drug resistance/rational drug use分类
医药卫生
