摘要
Abstract
Objective To explore the effects of megestrol acetate ( MA ) on nutritional status, anorexia score and cancer related fatigue in patients with end-stage malignant tumors. Results 82 cases of patients with end-stage rectal cancer who were admitted from Decem-ber 2012 to December 2014 were selected as the study objects. According to the random number table method, the patients were randomly divided into the control group and the observation group, 41 cases in each group. The control group was given supportive treatment;the observation group, based on the treatment in the control group, was treated with oral MA 160 mg which was divided into 2 times to take;both groups took 4 weeks as 1 cycle and were treated for 2 cycles. Nutritional status and improvement of weight in the 2 groups were evaluated after treatment. The Chinese Version ( CFS ) of anorexia score and cancer related fatigue scale was issued. Results The rate of gaining weight in the observation group was 60. 98%, which was significantly higher than 21. 95% in the control group( P < 0. 05). After treatment, serum albumin ( ALB ) was ( 35. 16 ± 5. 68 ) g/L and prealbumin ( PA ) was ( 286. 35 ± 29. 6 ) mg/L in the observation group, which were significantly higher than ( 28. 63 ± 4. 17 ) g/L, ( 221. 05 ± 23. 77 ) mg/L in the control group ( P < 0. 05 ); the scores of anorexia ( 1. 32 ± 0. 69 ) , body fatigue ( 11. 26 ± 4. 59 ) , emotional fatigue ( 6. 63 ± 2. 04 ) , cognitive fatigue ( 4. 53 ± 3. 20 ) and CFS total score ( 20. 64 ± 3. 36 ) were significantly higher than ( 1. 87 ± 0. 43 ) , ( 15. 48 ± 5. 23 ) , ( 9. 03 ± 2. 70 ) , ( 7. 64 ± 3. 05 ) , ( 30. 58 ± 4. 69 ) in the control group ( P < 0. 05 ) . The 30 d survival rate in the observation group was 73. 17%, which was significantly higher than 51. 22%in the control group; the median survival time in the observation group was ( 39. 64 ± 12. 06 ) d, which was significantly longer than ( 21. 07 ± 9. 68 ) d of the control group ( P < 0. 05 ) . Conclusion MA can improve the appetite of patients with end-stage malignant tumors. It can improve the nutritional status and cancer-related fatigue.关键词
终末期/恶性肿瘤/甲地孕酮/厌食评分/癌因性疲乏Key words
end-stage/malignant tumor/megestrol acetate/anorexia score/cancer-related fatigue分类
医药卫生
