摘要
Abstract
Objective To investigate the efficacy of thymalfasin neoadjuvant therapy on elderly patients with acute exacerbation of chronic obstructive pulmonary disease, and to observe its influence on the cellular immune function. Methods A retrospective analysis was car-ried out on the clinical data of 60 patients with acute exacerbation of chronic obstructive pulmonary disease in the hospital from March 2013 to May 2015, of which 30 cases were treated with conventional anti-infection treatment as the control group;the other 30 cases, on the basis of conventional therapy, were added with thymalfasin new adjuvant therapy as the treatment group. The blood-Qi analysis and pulmonary function, clinical symptom scores, C-reactive protein, the percentage of neutrophils, immune function changes were ob-served before and after treatment, and the efficacy and adverse reactions were recorded. Results After treatment, the PO2 and PCO2, FEV1/FVC, the percentage of FEV1 in the predicted value in the two groups increased or decrease significantly compared with before treatment ( P < 0. 05 );but the indicators of the two groups showed no statistically significant difference ( P > 0. 05 ) . After treatment, the clinical symptom scores and C-reactive protein and the percentage of neutrophils of the two groups significantly decreased than before treatment, and the decrease in the treatment group was more significant than the control group ( P < 0. 05 ) . The CD4+ /CD8 + ratio in the control group was significantly better than before treatment, besides that, the rest of the indicators showed no significant change. However, all the indicators of the observation group improved significantly, and each improvement was better than the control group ( P < 0. 05 ) . The total effective rate of the treatment group was 93. 33%, which was significantly higher than 63. 33% of the con-trol group ( P < 0. 05 ) . Conclusion The application of thymalfasin new adjuvant therapy for treating elderly patients with acute exacer-bation of chronic obstructive pulmonary disease can not only have significant efficacy, but also improve immune function in the patients, which is worthy of clinical promotion.关键词
慢性阻塞性肺疾病/急性加重期/胸腺法新/老年/免疫功能Key words
chronic obstructive pulmonary disease/acute exacerbation/thymalfasin/elderly/immune function分类
医药卫生
