摘要
Abstract
Objective To evaluate the efficacy of ganciclovir combined with prednisone and human immunoglobulin for treating serious herpes zoster in middle-aged and elderly patients. Methods Patients with herpes zoster were randomly divided into two groups in ac-cordance with the order of treatment patients, the observation group with 42 patients was treated with ganciclovir plus prednisone ( 0. 5 mg/kg·d ) combined with low dose of human immunoglobulin ( 2. 5-5 g ) , and the control group with 38 patients was treated with-out using human immunoglobulin. The blister stop time, scab beginning time, complete decrustation time and hospitalization time, as well as the visual analogue scale ( VAS ) 4, 8 d, 1, 2 month after treatment were observed in the two groups. Results The blister stop time, scab beginning time, complete decrustation time and hospitalization time of the observation group were obviously lower than those of the control group ( t=4. 93, 6. 12, 2. 82, 3. 20, P < 0. 05 ) . The VAS scores 4, 8 d, 1, 2 month after treatment of the observation group were obviously lower than the control group ( t=2. 40, 3. 34, 3. 12, 3. 31, P < 0. 05 ) , the neuralgia incidence was also obviously reduced, and the effective rate in the observation group was obviously higher than that of the control group (χ2=3. 90, P < 0. 05 ) . Conclusion Gan-ciclovir plus prednisone combined with low dose human immunoglobulin can significantly improve the treatment of elderly patients with severe herpes zoster, and promote the recovery of skin lesions, reducing the incidence of postherpetic neuralgia.关键词
更昔洛韦/强的松/人免疫球蛋白/带状疱疹Key words
ganciclovir/prednisone/human immunoglobulin/herpes zoster分类
医药卫生
