摘要
Abstract
Objective To explore clinical efficacy and adverse reactions of paroxetine combined with olanzapine in the treatment of de-pression combined with sleep disorder. Methods 200 patients with depression combined with sleep disorder in the hospital were divided into the control group and the experimental group. The control group was treated with paroxetine therapy, patients in the experimental group by paroxetine combined with olanzapine treatment. The clinical efficacy and adverse reactions of two groups were com-pared. Results After treatment, the total effective rate of the experimental group was 90. 00% , which was significantly higher than 70. 00% of the control group (χ2=12. 54, P < 0. 05 );the sleep latency in the experimental group was ( 0. 64 ± 0. 28 ) h, awakening time ( 1. 92 ± 0. 58 ) h, the number of awakening ( 1. 02 ± 1. 28 ) times, which were obviously lower than ( 3. 12 ± 1. 33 ) h, ( 3. 04 ± 1. 65 ) h, ( 3. 92 ± 1. 13 ) times of the control group;the total sleep time of the experimental group was ( 8. 46 ± 4. 94 ) h, which was significantly higher than ( 4. 89 ± 2. 53 ) h of the control group ( P < 0. 05 ); the incidence rate of adverse reactions in experimental group was 3. 00%, which was significantly lower than 52. 00% of the control group (χ2= =6. 07, P < 0. 05 ) . Conclusion Paroxetine combined with olanzapine in the treatment of patients with depression complicated with sleep disorder, rapid onset, good curative effect, safe and reliable with less adverse reaction.关键词
抑郁症/睡眠障碍/帕罗西汀/奥氮平Key words
depression/sleep disorders/paroxetine/olanzapine分类
医药卫生
