中国卒中杂志2016，Vol.11Issue(5)：344-348,5.DOI:10.3969/j.issn.1673-5765.2016.05.003
不同抗血小板聚集治疗方案对高原缺血性卒中治疗对比研究
Comparative Study of Different Antiplatelet Therapy on Treatment of High Altitude Ischemic Stroke
吉维忠 1吴世政 1胡全忠 1侯倩 1才鼎 1王进鹏1
作者信息
- 1. 810007 西宁青海省人民医院神经内科
- 折叠
摘要
Abstract
Objective To explore the effects of different antiplatelet therapies on treatment of high altitude ischemic stroke. Methods A total of 90 patients with acute ischemic stroke within 24 h after onset admitted by Dept. of Neurology of Qinghai People’s Hospital during March, 2014 and March, 2015 were enrolled into study and were randomly divided into two groups. Patients in both groups received correspondent comprehensive internal medicine treatment. The control group was treated with aspirin (100 mg/d), and the observation group were treated with Polivy-aspirin combination therapy (Polivy 75 mg/d, aspirin 100 mg/d). The corresponding National Institutes of Health Stroke Scale (NIHSS) score changes at 14 d and 28 d after treatment, progressive stroke and the incidence of post infarction hemorrhage rate and mortality, clinical efifcacy analysis of two groups were compared. Results The post-treatment NIHSS of both groups were signiifcantly reduced compared with NIHSS before treatment. However, the NIHSS of the observation group after treatment at 14 d and 28 d were 5 (3, 7) and 4 (3, 6), which was signiifcantly lower than NIHSS of the control group (P=0.03,P=0.02, respectively). In terms of progressive stroke occurrence, the occurrence rate of the observation group after treatment was only 11.1% (5 cases), which was signiifcantly lower than that of the control group of 35.5% (16 cases) (P=0.04). There were no signiifcant differences in hemorrhage conversion rate and mortality rate within 28 d after ischemic stroke. <br> Conclusion Polivy-aspirin combination therapy has good therapeutic effect on high altitude acute ischemic stroke with no increase of risk of hemorrhage conversion.关键词
阿司匹林/高原/缺血性卒中/方案/临床效果Key words
Aspirin/High altitude/Ischemic stroke/Therapy/Clinical effect引用本文复制引用
吉维忠,吴世政,胡全忠,侯倩,才鼎,王进鹏..不同抗血小板聚集治疗方案对高原缺血性卒中治疗对比研究[J].中国卒中杂志,2016,11(5):344-348,5.
