中国卒中杂志2016，Vol.11Issue(5)：349-354,6.DOI:10.3969/j.issn.1673-5765.2016.05.004
肱动脉内皮依赖性舒张功能障碍与非心源性缺血性卒中复发关系研究
Association between Brachial Artery Endothelium-dependent Vasodilatation Dysfunction and Reccurence of Non-cardiogenic Cerebral Ischemic Stroke
李沛 1张俊霞 1唐莉 1张蓉 1华国勇 2胡全忠 1侯倩1
作者信息
- 1. 810007 西宁青海省人民医院神经内科
- 2. 青海省人民医院超声科
- 折叠
摘要
Abstract
Objective To explore the relationship between brachial artery endothelium-dependent vasodilatation dysfunction and 1-year recurrence of non-cardiogenic cerebral ischemic stroke. Methods In our prospective observational study, patients with the ifrst acute non-cardioembolic ischemic stroke hospitalized in the Department of Neurology, The People's Hospital of QingHai Province were enrolled consecutively. According to lfow mediated diameter (FMD) percent change, these patients were divided into three groups: non-cardiac ischemic stroke combined with severe FMD damage group, non-cardiac ischemic stroke combined with mild FMD damage group, and pure non-cardiacischemic stroke group with normal FMD group. Then the baseline information were collected. The patients were followed up at 12th month. The amounts of ischemic stroke recurrence events and the influencing factors were compared with the results taken previously among different groups using Logistic regression analysis. Results A total of 126 patients were enrolled into study and 123 patients ifnished follow-up. Among which, 25 patients had severe FMD damage, 52 had mild FMD damage, and 46 had normal FMD. The recurrence rates of three groups after one year were as follows: 32.0% (n=8), 23.1% (n=12) and 8.7% (n=4), respectively. The statistics results showed that the number of non-cardiac ischemic stroke combined with severe FMD damage group's ischemic stroke recurrence events was signiifcant different compared with normal FMD group (P=0.016). According to the Logistic regression analysis, it showed that FMD severe damage (odds ratios [OR] 6.155, 95% conifdence interval [CI] <br> 1.333~28.420,P=0.020), hypertension (OR 3.286, 95%CI 1.069~10.104,P=0.038), diabetes (OR 3.657, 95%CI 1.135~11.777,P=0.030), C-reaction protein (CRP) (OR 1.053, 95%CI 1.001~1.107,P=0.045) were related with the recurrence of ischemic stroke, which were also the independent risk factors at the same time. Conclusion Severe FMD damage is associated with 1-year recurrence of ischemic stroke and is the independent risk factor for the recurrence of stroke.关键词
肱动脉内皮依赖性舒张功能/非心源性/缺血性卒中/复发Key words
Brachial artery endothelial-dependent vasodilation/Non-cardiogenic/Ischemic stroke/Recurrence引用本文复制引用
李沛,张俊霞,唐莉,张蓉,华国勇,胡全忠,侯倩..肱动脉内皮依赖性舒张功能障碍与非心源性缺血性卒中复发关系研究[J].中国卒中杂志,2016,11(5):349-354,6.
