摘要
Abstract
Objective To explore the value of apparent diffusion coefifcient (ADC) in differentiating stages and in determining ischemic penumbra of acute cerebral infarction. Methods A total of 62 patients who were diagnosed as acute cerebral infarction by clinical and imaging and underwent magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) examinations were enrolled into study. All cases were divided into <6 h group, 6~24 h group, 24~48 h group and 48~72 h group according to the period after onset by MRI detection. ADC values of the lesions, contralateral normal area, lesion center and edge in each time period were measured. Results Ten cases who’s onset time were less than 6 hours, the positive rate of conventional MRI was 0 (0/10) while the DWI detection rate was 100% (10/10); 52 cases who’s onset time were from 6~72 h, which included 6~24 h (27 cases), 24~48 h (13 cases), 48~72 h (12 cases), the positive rate of conventional MRI was 88.4% (46/52) while the DWI positive detection rate was 100% <br> (52/52). The ADC values of the lesions and contralateral normal area in each time period were: <6 h (0.601±0.079, 1.261±0.085) ×10-3mm2/s, 6~24 h (0.623±0.097, 1.152±0.083) ×10-3mm2/s, 24~48 h (0.635±0.103, 1.036±0.112) ×10-3mm2/s, 48~72 h (0.631±0.082, 1.225±0.097) ×10-3mm2/s; ADC values of the lesions and contralateral normal area in different time had signiifcant difference (P=0.006, 0.007, 0.008 and 0.017). ADC values showed no significant differences in different groups. The ADC values of lesion center and edge were: <6 h (0.547±0.089, 0.624±0.096) ×10-3mm2/s, which had significant difference (P=0.027); 6~24 h (0.572±0.074, 0.647±0.107) ×10-3mm2/s, which had significant difference (P=0.032); 24~48 h (0.615±0.104, 0.636±0.082) ×10-3mm2/s, which had no signiifcant difference; 48~72 h (0.631±0.081, 0.625±0.102) ×10-3mm2/s, which had no signiifcant difference. Conclusion DWI can ifnd the responsible lesions of acute cerebral infarction early and accurately, and it also can identify the lesion center and edge (<24 h), the edge of lesion may be ischemic penumbra, but it has little signiifcance in differentiating different stages of acute cerebral infarction (0~3 d).关键词
脑梗死/磁共振成像/弥散加权成像Key words
Cerebral infarction/Magnetic resonance imaging/Diffusion-weighted imaging
