摘要
Abstract
Objective To study the changes of corpus callosum network connectivity in leukoaraiosis (LA) patients by diffusion tensor imaging (DTI), and investigate the association between this change and cognitive impairment. <br> Methods This study is a single-center prospective cohort study. The subjects were divided into two groups: (1) LA group (n=30) who had extensive LA according to Fazekas scale, including two subgroups with normal cognition and mild cognitive impairment;(2) Control group (n=20) who had normal brain magnetic resonance images (MRI). All subjects underwent baseline examinations, including a questionnaire about the risk factors of cerebrovascular disease, blood tests, cognitive assessments and 3.0T brain MRI scan, including lfuid attenuated inversion recovery (FLAIR) and DTI sequences. DTI datum were processed by PANDA software and the quantitative values about fractional anisotropy (FA) and mean diffusivity (MD) in corpus callosum were extracted. The relationship between cognitive impairment and the changes of FA&MD was analyzed by Pearson’s correlation analysis. <br> Results There were no signiifcant differences of the baseline levels in two group, including sex, age, education, risk factors of cerebrovascular disease and some blood biochemical indexes, P>0.05.The scores about Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were signiifcantly lower in LA group than in control’s, P values were 0.002 and 0.008 respectively. The FA values in the genu (P=0.000), body (P=0.000) and splenium (P=0.026) of corpus callosum were signiifcantly lower in LA group than in control’s, but the MD’s were just to the contrary, P values were 0.013, 0.006 and 0.007 respectively. There was positive relation between cognitive impairment and lower FA value of corpus callosum, and the correlation coefficients declined gradually from the genu (r=0.78) to splenium (r=0.41) of corpus callosum. <br> Conclusion The changes of network connectivity in corpus callosum exist in LA patients, and FA decline in corpus callosum is positively related to cognitive impairment.关键词
脑白质疏松/弥散张量成像/胼胝体/网络连接性/认知功能损害Key words
Leukoaraiosis/Diffusion tensor imaging/Corpus callosum/Network connectivity/Cognitive impairment
