中华灾害救援医学2016，Vol.4Issue(6)：310-314,325,6.DOI:10.13919/j.issn.2095-6274.2016.06.003
RTE对病毒性肝炎肝纤维化分级诊断的meta分析
Diagnostic accuracy of hepatic ifbrosis stage by Real-Time Tissue Elastography with viral hepatitis：a meta-analysis
摘要
Abstract
Objective To evaluate the overall accuracy of real-time tissue elastography (RTE) for the staging of liver fibrosis with viral hepatitis by meta-analysis.Methods Systematic retrieval of domestic and foreign literature database for both original Chinese and English-language articles about RTE for the staging of liver fibrosis with viral hepatitis. The quality of studies included in this study were assessed using the Quality Assessment of Studies of Diagnostic Accuracy included in Systematic Review (QUADAS-2).For each cut-off stage of fibrosis, i.e., F≥1, F≥2, F≥3, and F≥4 (METAVIR), a bivariate random effects model were used to obtain overall sensitivity and specificity, summary receiver operating characteristic (SROC) curve was performed and the area under the curve (AUC) was calculated, the risk of publication bias was judged by funnel plots.Results 1152 articles related were searched,of which 17 studies used in the meta-analysis. A total of 2238 participants were included, the median age was 44.60 and 55.60% of the subjects were men. The chi-square tests of heterogeneity for sensitivity were all significant (χ2=24.38,P=0.0589 for F≥2;χ2=69.53,P<0.001 for F≥3;χ2=35.59,P=0.0003 for F≥4. ), as were the tests for heterogeneity of specificity (χ2=47.76,P<0.001 for F≥2;χ2=83.42,P<0.001 for F≥3;χ2=42.11,P=0.0001 for F≥4). The significant heterogeneity in both sensitivity and specificity warrants the use of a random-effects model. Summary of sensitivity and specificity were 0.79 and 0.76 for F≥2, 0.72 and 0.73 for F≥3, and 0.76 and 0.82 for F≥4, respectively. And the area under curve (AUC) of summary receiver operating characteristic (SROC) curve of F≥2 is 0.866,F≥3,0.859;F≥4,0.864,respectively.Conclusions RTE has certain value for the diagnosis of liver fibrosis grading in chronic hepatitis, but cannot replace liver biopsy technique.关键词
肝纤维化/肝硬化/实时组织弹性成像Key words
liver fibrosis/liver stiffness/real-time tissue elastography分类
医药卫生引用本文复制引用
刘刚,李孟天,丰锦春,张士杰,吴向未,孙红,彭心宇..RTE对病毒性肝炎肝纤维化分级诊断的meta分析[J].中华灾害救援医学,2016,4(6):310-314,325,6.基金项目
国家科技援疆专项 （）
