神经药理学报2015，Vol.5Issue(4)：1-7,7.
再灌注早期高血糖加重脑卒中脑糖的增加
Hyperglycemia in Acute Reperfusion Aggravates Cerebral Glucose Increase after Stroke
摘要
Abstract
[ABSTRACT]Objective:To explore the effects of hyperglycemia on cerebral glucose level and brain injury after ischemic stroke.Methods:The middle cerebral artery occlusion(MCAO) model was used to mimic the ischemic stroke. Hyperglycemia in acute reperfusion was induced by single intraperitoneal injection of 50% glucose(6 mL·kg-1) at 5 min before reperfusion in MCAO-treated rats. After reperfusion for 30 min and 24 h,the cerebral glucose levels were detected,and the neurological score and infarct areas were assessed.Results:After glucose administration,the blood glucose increased significantly and lasted for 120 min after reperfusion (P<0.05). Ischemia and reperfusion injury caused cerebral glucose increase. Hyperglycemia in acute reperfusion significantly aggravated the elevation of cerebral glucose,and increased the neurological scores and infarct areas after reperfusion for 24 h(P<0.05).Conclusion:After cerebral ischemia,hyperglycemia in acute reperfusion could aggravate cerebral glucose increase and stroke injury. The elevation of cerebral glucose levels might directly mediate aggravation of stroke injury caused by hyperglycemia.关键词
脑卒中/缺血再灌注/高血糖/脑糖Key words
stroke/ischemia and reperfusion/hyperglycemia/cerebral glucose分类
医药卫生引用本文复制引用
张帅,夏聪媛,周恒,杨鹏飞,陈乃宏..再灌注早期高血糖加重脑卒中脑糖的增加[J].神经药理学报,2015,5(4):1-7,7.基金项目
国家自然科学基金项目（No.81274122、No.81173578、No.81202507、No.81373997），国家“重大新药创制”科技重大专项项目（No.2012ZX09301002-004、No.2012ZX09103101-006、No.2012ZX09301002-001），国家高技术研究发展计划（863计划）项目（No.2012AA020303），教育部长江学者和创新团队发展计划（PCSIRT）项目（No.IRT1007），教育部博士点基金重点项目（No.20121106130001），北京市自然科学基金（No.7131013、No.7142115），新药作用机制研究与药效评价北京市重点实验室资助项目 （）
