神经药理学报2015，Vol.5Issue(4)：43-54,12.
阿尔茨海默病治疗中相关雌激素信号途径的研究进展
Research Progress of Estrogen Signal Pathway in Alzheimer’s Disease
摘要
Abstract
Alzheimer’s disease(AD) is a common neurodegenerative disease,and main symptoms are progressive cognitive dysfunction and memory deterioration. Numerous clinical and epidemiological studies show that there is a gender difference in the incidence ofAD,women are more likely to develop AD post-menopause,which indicated that the lack of estrogen is a risk factor of AD. Recent research has proposed estrogen can directly reduce the accumulation of senile plaque and neurofibrillary tangles. Studies have shown that estrogen may have neuroprotective effects,while clinical trials of women post-menopausal show no obvious effects of estrogen on AD. The discrepancies may relate to the selectivity of estrogen receptors. This review will make a brief summary on AD related estrogen and estrogen receptors such as ER alpha or ER beta subtype,further discussing selective ligands of estrogen receptors to provide a safe and effective treatment to AD.关键词
雌激素/雌激素受体/阿尔茨海默病Key words
estrogen/estrogen receptor/Alzheimer’s disease分类
医药卫生引用本文复制引用
刘杨,沈丽霞..阿尔茨海默病治疗中相关雌激素信号途径的研究进展[J].神经药理学报,2015,5(4):43-54,12.基金项目
河北省自然科学基金资助项目（No.H2012405016），河北省高等学校科学技术研究项目 （）
