中外医学研究2016，Vol.14Issue(14)：151-153,3.DOI:10.14033/j.cnki.cfmr.2016.14.083
串联质谱法对早产儿TPN营养支持代谢的研究
Study of Tandem Mass Spectrometry on Nutrition Metabolism in Preterm Infants with TPN
冯丽燕 1王德胜1
作者信息
- 1. 东莞市第五人民医院 广东 东莞 523900
- 折叠
摘要
Abstract
Objective:To explore the value of tandem mass spectrometry in the study on nutrient metabolism in preterm infants.Method:Sixty-two preterm infants with gestational age of 28-33 weeks admitted to our hospital from June 2014 to September 2015 were selected as the objects,after the implementation of TPN for 48-72 hours,their finger blood were sampled,then the concentration of amino acids and acylcarnitines spectrum in blood smear were analyzed by tandem mass spectrometry(MS-MS).Result:Eleven cases of all the preterm infants revealed a positive results,2 cases of hyperornithinemia,3 cases of tyrosinemia,2 cases of propionic acidemia,1 case of methylmalonic acidemia,2 cases of carnitine transport barriers,and 1 case of isovaleric acidemia.Conclusion:The tandem mass spectrometry technique can detect the nutrition metabolic substance levels in preterm infants and guide the clinical nutritional support program.关键词
串联质谱/早产/营养代谢/氨基酸类/肉碱Key words
Tandem mass spectrometry/Premature/Nutrition metabolism/Amino acids/Carnitine分类
医药卫生引用本文复制引用
冯丽燕,王德胜..串联质谱法对早产儿TPN营养支持代谢的研究[J].中外医学研究,2016,14(14):151-153,3.
