中国现代中药2016，Vol.18Issue(5)：558-562,594,6.DOI:10.13313/j.issn.1673-4890.2016.5.004
葛花、枳蓂子配伍对慢性酒精性肝损伤大鼠海马7种单胺类神经递质及代谢产物含量水平的影响
Effectiveness of Compatibility of Flos Puerariae Lobatae and Semen Hoveniae on 7 Kinds Monoamine Neurotransmitters and Their Metabolites in Hippocampal Tissue of Rats with Chronic Alcoholic Liver Injury
摘要
Abstract
Objective:To examine the effectiveness of compatibility of Flos Puerariae Lobatae and Semen Hoveniae on 7 kinds of monoamine neurotransmitters and their metabolites in hippocampal tissue of rats with chronic alcoholic liver injury from two aspects-the compatibility dosage and dosing cycle.Methods:The rats model with chronic alcoholic liver injury were induced by administrating wine.The rats randomly divided into blank control group,model group,positive control group,and compatibility groups with dose difference (low,medium and high doses).After 4,8 and 12 weeks,hippocampus were rapidly removed and frozen immediately.HPLC-ECD was used to test the expression of monoamine neurotransmitters and their metabolites of hippocampal tissue in rats.Results:After 4 weeks,in comparison to model group,the content of 5-HT in the three compatibility doses groups were changed with statistically significant.The content of NE in the medium and high doses group were changed with statistically significant.The content change of HVA and E in the medium dose group were changed with statistically significant.After 8 weeks,In comparison to model group,the content of 5-HT in the three compatibility doses groups were changed with statistically significant.The content of 5-HIAA in the medium and high doses group were changed with statistically significant;the content change of DA in the medium dose group were changed with statistically significant.After 12 weeks,In comparison to model group,the content of 5-HIAA in the low and high doses group were changed with statistically significant.The content change of NE in the medium dose group were changed with statistically significant.Conclusion:Compatibility of Flos Puerariae Lobatae and Semen Hoveniae could affect the expression of monoamine neurotransmitters and their metabolites in hippocampal tissue of rats with chronic alcoholic liver injury.关键词
葛花/枳蓂子/配伍/单胺类神经递质/慢性酒精性肝损伤Key words
Flos Puerariae Lobatae/Semen Hoveniae/compatibility/monoamine neurotransmitter/alcoholic liver injury引用本文复制引用
王旭,张傲哲,陈绍红,钟赣生,柳海艳,王茜,刘明,赵桐,于雪,范盎然..葛花、枳蓂子配伍对慢性酒精性肝损伤大鼠海马7种单胺类神经递质及代谢产物含量水平的影响[J].中国现代中药,2016,18(5):558-562,594,6.基金项目
［基金项目］国家自然科学基金 （）
