重庆医学Issue(22)：2594-2596,3.DOI:10.3969/j.issn.1671-8348.2013.22.010
MicroRNA-144在结肠癌中的表达水平及临床意义
Clinical significance of microRNA-144 expression in colon tumor
张广钰 1钟漓 1田小林 1戴凌 1朱袭嘉 1蒋志庆1
作者信息
- 1. 桂林医学院附属医院胃肠外科,广西桂林,541001
- 折叠
摘要
Abstract
Objective To investigate the expression of microRNA-144 and its association with clinic-pathological features in co-lon tumor.Methods The expression levels of microRNA-144 in 38 colon tumors and their matched non-tumor adjacent tissue speci-mens were detected by using stem-loop real-time reverse transcription-polymerase chain reaction(RT-qPCR),and their correlation with clinic-pathologic features of colon tumor was analyzed.Results Expression levels of microRNA-144 were significantly higher in tumor tissues than in adjacent normal tissues(P<0.05),the median of comparative expression level was 2.30.The expression of microRNA-144 was associated with TNM stage(P<0.05)and cell differentiation(P<0.05).ROC curve of microRNA-144 about cell differentiation and resulted in a diagnostic sensitivity of 88% and specificity of 61.3%.Conclusion The level of microRNA-144 expression may be a valuable adj uvant parameter in forecasting the poorly differentiated colon tumor.关键词
microRNA-144/结肠癌/细胞分化/淋巴结转移Key words
microRNA-144/colon tumor/cell differentiation/lymphatic metastasis引用本文复制引用
张广钰,钟漓,田小林,戴凌,朱袭嘉,蒋志庆..MicroRNA-144在结肠癌中的表达水平及临床意义[J].重庆医学,2013,(22):2594-2596,3.
