南方医科大学学报Issue(9)：1336-1340,5.DOI:10.3969/j.issn.1673-4254.2013.09.18
膀胱尿路上皮癌中CD133、CD82/KAI1的表达及其与血管生成拟态的关系
Expressions of CD133 and CD82/KAI1 in bladder urothelial carcinoma and their correlation with vasculogenic mimicry
摘要
Abstract
Objective To explore the expressions of CD133 and CD82/KAI1 in bladder urothelial carcinoma, their association with the clinicopathological factors and their roles in vasculogenic mimicry (VM) in the tumor. Methods The expressions of CD133 and CD82/KAI1 and VM were detected by immunohistochemistry and histochemistry in 90 specimens of bladder urothelial carcinoma and 20 specimens of normal bladder epithelium tissue. Results The positivity rates of CD133, CD82/KAI1 and VM in normal bladder epithelium tissue were 0, 90%and 0, showing significant differences from the rates of 65.6%, 31.1%and 31.1%in urothelial carcinoma, respectively (P<0.01). Positive expressions of CD133, CD82/KAI1 and VM were significantly correlated with pTNM stage and tumor relapse (P<0.01) but not with gender, age, or tumor numbers (P>0.05). CD133 expression was positively correlated with VM (P=0.487, P<0.05), and CD82/KAI1 expression was negatively correlated with VM (r=-0.452, P<0.01) and CD133 (r=-0.776, P<0.05). Conclusion The expressions of CD133 and CD82/KAI1 proteins are involved in the occurrence of VM in bladder urothelial carcinoma to contribute to the invasion and relapse of bladder carcinoma.关键词
膀胱尿路上皮癌/CD133/CD82/KAI1/血管生成拟态/免疫组织化学Key words
bladder urothelial carcinoma/CD133/CD82/KAI1/vasculogenic mimicry/immunohistochemistry引用本文复制引用
俞岚,武世伍,周蕾,宋文庆,王丹娜..膀胱尿路上皮癌中CD133、CD82/KAI1的表达及其与血管生成拟态的关系[J].南方医科大学学报,2013,(9):1336-1340,5.基金项目
2012年安徽省高等学校省级优秀青年人才基金项目 （）
