临床与病理杂志2015，Vol.35Issue(1)：128-131,4.DOI:10.3978/j.issn.2095-6959.2015.01.029
食管癌放疗敏感性与个体化治疗
Radio-sensitivity and individualized radiation therapy in esophageal cancer
摘要
Abstract
Radiation therapy is an effective, safe, and common method in treating esophageal cancer, and one of the major approaches in a multi-disciplinary team. However, failure of local control is the primary cause of treatment failure. Therefore, increasing radio-sensitivity is the key point. Radio-sensitizer can improve radio-sensitivity of tumor cels effectively and attract attention in radiation oncology research. With the companion of proper radio-sensitizer, patients can not only show the more excellent sensitivity to chemo-radiotherapy but also tolerate side effects in the traditional dose. This manuscript focuses on translational and clinical research of esophageal cancer, in the perspective of hypoxia, angiogenesis, and apoptosis, and strives to provide new ideas for comprehensive treatment of esophageal cancer. It is direction of future to develop new drugs targeting novel molecules in cancer cels, which is also important in individualized medicine.关键词
食管癌/放疗敏感性/个体化治疗/放射治疗Key words
radiosensivity/esophageal cancer/hypoxia/angiogenesis/apoptosis引用本文复制引用
祝鸿程,葛小林,杨跃骅,陈晓晨,张皓,杨艳,杨曦,秦嗪..食管癌放疗敏感性与个体化治疗[J].临床与病理杂志,2015,35(1):128-131,4.基金项目
江苏省一级学科重点学科"特种医学"基金 （）
江苏省高等学校优势学科项目基金 （）
国家自然科学基金 （）
江苏省2014年度普通高校研究生科研创新计划项目.This work was supported by the Key Academic Discipline of Jiangsu Province"Medical Aspects of Specific Environments" （）
Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) (JX10231801) （PAPD）
Natural Science Foundation of China (81272504, 81472809) （81272504, 81472809）
Research and Innovation Project for College Graduates of Jiangsu Province (KYLX_0955), P.R. China. （KYLX_0955）
