临床与病理杂志2015，Vol.35Issue(1)：150-154,5.DOI:10.3978/j.issn.2095-6959.2015.01.034
ICAM-1与支气管哮喘的研究进展
Advances in intercellular adhesion molecule-1 and bronchial asthma
摘要
Abstract
Intercellular adhesion molecule-1 (ICAM-1, CD54) is a member of the immunoglobulin (Ig) superfamily. It is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into inflammatory tissue. Migration of leukocytes from the systemic circulation into inlfamed lung tissue is mediated by interactions between leukocyte surface and endothelial adhesion molecules (e.g., ICAM-1), which plays an important role in the pathogenesis of asthma. In this review we wil elaborate the progress of ICAM-1 and its expression regulation in asthma research.关键词
ICAM-1/sICAM-1/白细胞/支气管哮喘Key words
intercellular adhesion molecule-1/soluble intercellular adhesion molecule-1/leucocyte/bronchial asthma引用本文复制引用
邓艳凤..ICAM-1与支气管哮喘的研究进展[J].临床与病理杂志,2015,35(1):150-154,5.基金项目
国家自然科学基金(81270093) （81270093）
湖南省科技计划项目(2012FJ3075) （2012FJ3075）
湖南省自然科学基金(12JJ3111) （12JJ3111）
湖南省医药卫生科研计划课题(B2013-064).This work was supported by the National Natural Science Foundation of China (81270093) （B2013-064）
Science and Technology Programme of Hunan Province, China (2012FJ3075) （2012FJ3075）
the Natural Science Foundation of Hunan Province, China (12JJ3111) and Medical Health Research Plan of Hunan Province, China (B2013-064). （12JJ3111）
