Th细胞在类风湿关节炎发病作用的研究进展OACSTPCD
Research progress of Th cells in the pathogenesis of rheumatoid arthritis
T细胞功能紊乱,尤其是辅助性CD4+T细胞异常活化,在类风湿关节炎(rheumatoidarthritis,RA)的发生发展中处于中心环节,CD4+T细胞亚群Th1/Th2细胞及Th17/Treg细胞之间的失衡可能是RA发病的最直接和最重的因素.Th细胞相关细胞因子通过作用于多种细胞并相互调节形成一个复杂的网络,Th1和Th17细胞通过产生炎性细胞因子IFN、TNF-α、IL-2、IL-1、IL-17等造成了滑膜炎的发生,Th2和Treg细胞通过…查看全部>>
T cell function disorder, especially abnormal activated CD4+T helper cells, plays a central role in the occurrence and development of RA. The imbalance betweenTh1/Th2 cells and Th17/Treg cells in CD4+T cell subsets may be the most direct and important factors in the pathogenesis of RA. Th cell related cytokines by acting on a variety of cels and regulate each other to form a complex network, Th1 and Th17 cels through the production of inlfammatory cyto…查看全部>>
王建
山东中医药大学,基础医学院，济南 250355
Th细胞类风湿关节炎发病机制研究进展文献综述
Th cellsrheumatoid arthritispathogenesisresearch progress
《临床与病理杂志》 2015 (2)
263-266,4
山东省高等学校科技计划项目(J12 LK09). This work was supported by Planning Project of Science and Technology in Colleges and Universities in Shandong Province (J12 LK09), P. R. China.
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