柠檬醛交联壳聚糖微球的制备及评价OA北大核心CSCDCSTPCD
Preparation and Characteration of Chitosan Microsphere Crosslinked with Citral
为了开发绿色无毒的载药基材，以食品级柠檬醛为新型交联剂，采用乳化交联法制备壳聚糖载药微球。结果表明，柠檬醛交联壳聚糖载药微球成球性良好，表面致密；壳聚糖的氨基与柠檬醛的醛基发生交联反应形成席夫碱结构是柠檬醛交联壳聚糖微球形成的内因；柠檬醛交联壳聚糖载药微球的载药量和包封率分别可达186 g/kg 和91．2％，为开发安全的药物载体提供了一条新途径。
To develop a green and harmless drug-loaded materials ,the chitosan microspheres crosslinked with food-grade citral were prepared by emulsion crosslinking method .Results showed that chitosan microspheres crosslinked with citral had good sphericity and dense surface ;FT-IR spectrum verified the crosslink reaction between the amino groups from chitosan and the aldehyde from citral ;the drug loading and entrapment efficiency of the chitosan microspheres were 1…查看全部>>
罗华丽;张秀娟
烟台职业学院食品与生化工程系,山东烟台,264670烟台职业学院食品与生化工程系,山东烟台,264670
医药卫生
壳聚糖柠檬醛微球制备
chitosancitralmicrospherepreparation
《河南农业科学》 2013 (10)
157-159,3
山东省自然科学基金项目ZR2011BQ028）
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