摘要
Abstract
Objective To understand clinical distribution and antimicrobial resistance analysis of 4 380 patho-genic bacteria in nosocomial infection .Methods In 2011 the specimens of patients in the class 3A comprehensive hos-pital were performed by pathogen isolation ,identification and antimicrobial susceptibility test according to the routine detection ,the result was analyzed by using WHONET 5 .6 software .Results The hospital infection rate ranked in the top five departments was neurosurgery ,internal medicine ,trauma ,oncology and ICU ;In the 4 380 pathogenic bac-terial strains which were isolated from 7 326 clinical specimen ,the detection rate of about 59 .8% .The gram negative bacilli accounted for 75 .3% (3 300/4 380) ,gram positive cocci accounted for 19 .0% (831/4 380) ,the fungi was 5 .7% (249/4 380) .The top 10 pathogenic bacteria were as follows :Pseudomonas aeruginosa ,Klebsiella pneumoniae , Bauman Acinetobacter ,Escherichia coli ,Candida albicans ,coagulase-negative staphylococci ,Staphylococcus aureus , Enterococcus ,Enterobacter cloacae and Acinetobacter lwoffii .Methicillin-resistant Staphylococcus aureus (MRSA) positive rate was 49 .1% ,methicillin resistant coagulase negative staphylococcus (MRCNS ) detection rate was 81 .2% .Not detected on the glycopeptide resistance in Staphylococcus aureus ,extended-spectrum beta-lactamases (ESBLs) of Escherichia coli positive detection rate was 58 .9% ,ESBLs positive Klebsiella pneumoniae detection rate was 28 .9% .Conclusion A variety of factors resulting in patients with low immunity ,is conditional pathogenic bac-teria caused the main reason of hospital infection ;The main pathogen is gram-negative bacilli ,including Pseudomonas aeruginosa which is particularly obvious rise ,the proportion of fungal infection also has the obvious rise trend .Enter-obacteriaceae to carbapenems ,amikacin and piperacillin /tazobactam antibiotic resistance rate is relatively low ,which shows a trend of multidrug resistance in pseudomonas aeruginosa and acinetobacter bauman .关键词
耐药性/病原菌/医院感染Key words
drug resistance/pathogenic bacteria/nosocomial infection
