检验医学与临床Issue(18)：2353-2355,2358,4.DOI:10.3969/j.issn.1672-9455.2013.18.001
PTX-3在蛛网膜下腔出血后脑血管痉挛发病机制中的作用
Role of pentraxin-3 in pathogenesis with cerebral vasospasm after subarachnoid hemorrhage *
摘要
Abstract
Objective To investigate the mechanism of pentraxin-3 (PTX-3) in pathogenesis of cerebral vaso-spasm (CVS) after subarachnoid hemorrhage (SAH) .Methods The levels of white blood cell (WBC) ,neutrophil percentage (NE% ) and PTX-3 in cerebrospinal fluid (CSF) and peripheral blood from SAH patients and healthy subjects were detected respectively .Results WBC and NE% levels of peripheral blood and CSF in SAH group were significantly higher than healthy controls (P<0 .01 ,P<0 .05) .Serum and CSF PTX-3 levels in SAH group were significantly higher than healthy controls (P<0 .01 ,P<0 .05) .CSF levels of WBC ,NE% and PTX-3 in SAH pa-tients with CVS were higher than SAH patients without CVS (P<0 .05) ,but the difference of serum PTX-3 level was not significant (P> 0 .05) .On 1 ,2 ,3 ,5 and 7 days after SAH ,CSF and peripheral blood levels of WBC , NE% and PTX-3 in patients with CVS were significantly higher than healthy controls (P<0 .01) .Conclusion The pathogenesis of CVS might be with high level systemic and local inflammatory response in SAH patients .High level of PTX-3 in CSF might mediate the onset of CVS by inducing local inflammatory reaction .The occurrence of CVS could be dependent on the persistence of highly intensive inflammatory response ,of which PTX-3 might be the key mediating molecule .关键词
正五聚蛋白-3/蛛网膜下腔出血/脑血管痉挛/发病机制Key words
pentraxin-3/subarachnoid hemorrhage/cerebral vasospasm/pathogenesis引用本文复制引用
胡晓芳,袁笑,苏晓,王玉红,孟冬娅,安殿梅,郑伟..PTX-3在蛛网膜下腔出血后脑血管痉挛发病机制中的作用[J].检验医学与临床,2013,(18):2353-2355,2358,4.基金项目
辽宁省自然科学基金项目（201102240）。 （）
