张耀东 1梁继伟 1苑同业 1孙青菊 1王军 1梁冰1
作者信息
- 1. 解放军第四○一医院检验科,山东青岛,266071
- 折叠
摘要
Abstract
Objective To systematically assess the performance of carbohydrate deficient transferrin (CDT ) or its relative value (% CDT ) in the diagnosis of alcoholic liver disease (ALD ) .Methods Databases , including PubMed ,EMBASE ,CNKI ,WanFang and CSJD ,were retrieved for related articles about the application fo CDT in the diagnosis for ALD .MetaDisc1 .4 software was used to assess accuracy of it .Results Six studies met the eligibili-ty criteria and were included ,including 259 cases for ALD group ,308 cases for NALD group and 262 cases for nor-mal group .Meta analysis indicated that ,for the differential diagnosis between ALD group and NALD group ,the summary values of sensitivity (Se) ,specificity (Sp) ,positive likelihood ratio (+LR) ,negative likelihood ratio (-LR) , diagnostic odds ratio(DOR) and area under summary receiver operating curve(SROC AUC) were 72% ,82% ,4 .20 , 0 .34 ,15 .46 and 0 .866 7 ,and for the differential diagnosis between ALD group and normal group ,the summary values of Se ,Sp ,+LR ,-LR ,DOR and SROC AUC were 73% ,89% ,5 .62 ,0 .35 ,27 .76 and 0 .908 5 .Conclu-sion CDT or % CDT might be accurate for the exclusive diagnosis of ALD ,but should be combined with drinking history for the diagnosis of ALD .The results might need to be studied further in future .关键词
糖缺失性转铁蛋白/酒精性肝病/诊断Key words
carbohydrate deficient transferrin/alcoholic liver disease/diagnosis
