中国骨伤Issue(8)：705-708,4.DOI:10.3969/j.issn.1003-0034.2013.08.022
EphB4-EphrinB2双向信号传导在骨重建中的作用
Effects of bidirectional EphB4-EphrinB2 signaling on bone remodeling
摘要
Abstract
Bidirectional Eph-Ephrin signaling as a focal point of research in cell-cell communications is critical for gen-eration of nerves and vesssels as well as invation and metastasis of tumor cells. The roles for Ephrin-Eph bidirectional signaling in bone remodeling were important. EphrinB2 is expressed on osteoblasts and EphB4 is expressed on osteoclasts. Forward sig-naling through the EphB4 receptor into mesenchymal precursors promotes osteoblast differentiation ,while reverse signaling through the EphrinB2 ligand into osteoclast suppresses differentiation. Signaling between the ligand EphrinB2 and the recep-tors EphB4 explains bidirectional signaling between osteoblasts and osteoclasts ,bone absorption and remodeling ,which may lay a theoretical foundation for identifying drug targeting and preventing and treating bone loss.关键词
信号传导/骨重建/综述文献Key words
Signal transduction/Bone remodeling/Review literature引用本文复制引用
范文斌,赵建宁,包倪荣..EphB4-EphrinB2双向信号传导在骨重建中的作用[J].中国骨伤,2013,(8):705-708,4.基金项目
国家自然科学基金青年基金项目（编号81000814） Fund programYouth Projects of National Natural Science Foundation of China （）
